Severe medical issues can occur with cocaine use, which include cocaine use disorder and overdose. Also, adulteration of cocaine with really strong fentanyl and linked substances is A serious contributor to the increasing drug overdose deaths.Karl Koller (a detailed affiliate of Sigmund Freud, who'd create about cocaine later on) experimented with

The narcotic antagonists, naloxone or nalmefene, are specific antidotes for opioid overdose. Opioid antagonists shouldn't be administered inside the absence of clinically considerable respiratory or circulatory depression secondary to ROXICODONE (oxycodone hydrochloride) ® overdose. If essential the suitable dose of naloxone hydrochloride or nalme